Article
Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology.
The Journal of cell biology - 15 Apr 2013
Thomanetz Venus, Angliker Nico, Cloëtta Dimitri, Lustenberger Regula M, Schweighauser Manuel, Oliveri Filippo, Suzuki Noboru, Rüegg Markus A
Abstract excerpt
The mammalian target of rapamycin (mTOR) assembles into two distinct multi-protein complexes called mTORC1 and mTORC2. Whereas mTORC1 is known to regulate cell and organismal growth, the role of mTORC2 is less understood. We describe two mouse lines that are devoid of the mTORC2 component rictor in the entire central nervous system or in Purkinje cells. In both lines neurons were smaller and their morphology and...
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