Article

mTORC2-mediated cell-cell interactions promote BMP4-induced WNT activation and mesoderm differentiation

2024-06-07

Abstract excerpt

<h4>Summary</h4> The mechanistic target of rapamycin complex 2 (mTORC2) is essential for embryonic development but its underlying molecular mechanisms remain unclear. Here we show that disruption of mTORC2 in human embryonic stem cells (hESCs) considerably alters the Rho/Rac signaling dynamics and reduces cell adhesion. Despite this, mTORC2-deficient hESCs maintain self-renewal and expression of pluripotent marke...

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Literature Corpus work: 4a1e80dc-a135-592b-b179-2164d3b13983
DOI: 10.1101/2024.06.07.597881

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