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Article

Targeted-sequence of normal urothelium and tumor of patients with non-muscle invasive bladder cancer.

Scientific reports - 5 Oct 2022

Hayashi Yujiro, Fujita Kazutoshi, Sakai Kazuko, Adomi Shogo, Banno Eri, Nojima Satoshi, Tomiyama Eisuke, Matsushita Makoto, Kato Taigo, Hatano Koji, Kawashima Atsunari, Minami Takafumi, Morii Eiichi, Uemura Hirotsugu, Nishio Kazuto, Nonomura Norio

Abstract excerpt

During tumorigenesis, certain tissues are colonized by mutant clones with oncogenic driver mutations as precancer lesions. These mutations can facilitate clonal expansion and may contribute to malignant transformation. The molecular features of low-grade non-muscle invasive bladder cancer (NMIBC) and high-grade bladder cancer are so distinct that they are thought to follow different evolutionary tumorigenesis...

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Identifiers

PMID: 36198773
DOI: 10.1038/s41598-022-21158-8
PMCID: PMC9535027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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