Article
Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden.
Nature communications - 29 Apr 2014
Cazier J-B, Rao S R, McLean C M, Walker A K, Walker A L, Wright B J, Jaeger E E M, Kartsonaki C, Marsden L, Yau C, Camps C, Kaisaki P, Taylor J, Catto J W, Tomlinson I P M, Kiltie A E, Hamdy F C
Abstract excerpt
Bladder cancers are a leading cause of death from malignancy. Molecular markers might predict disease progression and behaviour more accurately than the available prognostic factors. Here we use whole-genome sequencing to identify somatic mutations and chromosomal changes in 14 bladder cancers of different grades and stages. As well as detecting the known bladder cancer driver mutations, we report the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.