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Article

Transmembrane topology of a CLC chloride channel.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 1997

Schmidt-Rose T, Jentsch T J

Abstract excerpt

CLC chloride channels form a large and conserved gene family unrelated to other channel proteins. Knowledge of the transmembrane topology of these channels is important for understanding the effects of mutations found in human myotonia and inherited hypercalciuric kidney stone diseases and for the interpretation of structure-function studies. We now systematically study the topology of human ClC-1, a prototype...

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Identifiers

PMID: 9207144
DOI: 10.1073/pnas.94.14.7633
PMCID: PMC23874

Genes

CLC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transmembrane topology of a CLC chloride channel.PMID 9207144Read ↗

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