Article

Human Kidney Alternative Splicing Information Illuminates Cardiovascular-Kidney-Metabolic Syndrome Risk

2025-10-13

Abstract excerpt

Alternative splicing generates multiple transcripts from a single gene, contributing to functional protein diversity. However, short read RNA sequencing often aggregates isoforms, limiting transcript-level resolution. By analyzing splicing variation in 404 human kidney cortical samples across a spectrum of disease severity, we define the splicing landscape of the human kidney in health and disease. To pinpoint lik...

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Literature Corpus work: 12ec316f-1870-54ee-a950-d91ad6db36bb
DOI: 10.1101/2025.10.02.25337157

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