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Transcriptome- and proteome-wide association studies nominate determinants of kidney function and damage

26 Jun 2023

Abstract excerpt

BACKGROUND: The pathophysiological causes of kidney disease are not fully understood. Here we show that the integration of genome-wide genetic, transcriptomic, and proteomic association studies can nominate causal determinants of kidney function and damage. RESULTS: Through transcriptome-wide association studies (TWAS) in kidney cortex, kidney tubule, liver, and whole blood and proteome-wide association studies...

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PMID: 37365616
DOI: 10.1186/s13059-023-02993-y

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