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Molecular insights into genome-wide association studies of chronic kidney disease-defining traits

9 Nov 2018

Abstract excerpt

Genome-wide association studies (GWAS) have identified >100 loci of chronic kidney disease-defining traits (CKD-dt). Molecular mechanisms underlying these associations remain elusive. Using 280 kidney transcriptomes and 9958 gene expression profiles from 44 non-renal tissues we uncover gene expression partners (eGenes) for 88.9% of CKD-dt GWAS loci. Through epigenomic chromatin segmentation analysis and variant...

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PMID: 30467309
DOI: 10.1038/s41467-018-07260-4

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