Article

Longitudinal single-cell data informs deterministic modelling of inflammatory bowel disease

2023-10-30

Abstract excerpt

<h4>ABSTRACT</h4> Single-cell mRNA sequencing (scRNA-seq) allows deep molecular and cellular profiling of immunological processes. Longitudinal scRNA-seq datasets can be used for deterministic ordinary differential equation (ODE)-based modelling to mechanistically describe immune dynamics. Here, we derived longitudinal changes in the abundance of six colonic cell types during inflammatory bowel disease (IBD) from...

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Literature Corpus work: 12ebe09d-474f-5660-9126-bfdf314e9eda
DOI: 10.1101/2023.10.27.561846

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