Article

Bacterial infection drives trained immunity through epigenetic remodeling of epithelial stem cells

2021-09-09

Abstract excerpt

<title>Abstract</title> <p>Recurrent bacterial infections are a major health burden worldwide, yet the mechanisms dictating host susceptibility to recurrence are poorly understood. Here we demonstrate that an initial bacterial infection of the urinary bladder with uropathogenic E. coli (UPEC) can induce sustained epigenetic changes in the bladder epithelial (urothelial) stem cells that reprogram the differentiate...

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Literature Corpus work: a1b9bc63-3a91-5dd2-a8e0-547268cee7d6
DOI: 10.21203/rs.3.rs-842556/v1

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