Article

TNF-NFkB-p53 axis restricts <i>in vivo</i> survival of hPSC-derived dopamine neuron

2023-03-31

Abstract excerpt

Ongoing, first-in-human clinical trials illustrate the feasibility and translational potential of human pluripotent stem cell (hPSC)-based cell therapies in Parkinson’s disease (PD). However, a major unresolved challenge in the field is the extensive cell death following transplantation with <10% of grafted dopamine neurons surviving. Here, we performed a pooled CRISPR/Cas9 screen to enhance survival of postmitoti...

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Literature Corpus work: 12e33599-b195-5e9b-a172-28716de66c51
DOI: 10.1101/2023.03.29.534819

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