Article

SAK3 confers neuroprotection in the neurodegeneration model of X-linked Dystonia-Parkinsonism

2024-04-25

Abstract excerpt

<title>Abstract</title> <p><underline>Background</underline> X-linked Dystonia-Parkinsonism(XDP) is an adult-onset neurodegenerative disorder that results in the loss of striatal medium spiny neurons (MSNs). XDP is associated with disease-specific mutations in and around the <italic>TAF1</italic> gene. This study highlights the utility of directly reprogrammed MSNs from fibroblasts of affected XDP individuals as...

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Literature Corpus work: 0ca36422-85ff-5edb-8770-c2b6614d551c
DOI: 10.21203/rs.3.rs-4068432/v1

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