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Article

Parkin mutation decreases neurite complexity and maturation in neurons derived from human fibroblasts.

Brain research bulletin - 1 Jun 2020

Pu Jiali, Gao Ting, Zheng Ran, Fang Yi, Ruan Yang, Jin Chongyao, Shen Ting, Tian Jun, Zhang Baorong

Abstract excerpt

BACKGROUND: Parkinson's disease (PD) is one of the most common neurodegenerative disorders, and mainly characterized by the progressive degeneration of dopaminergic (DA) neurons in the midbrain substantia nigra and non-DA neurons in many other parts of the brain. Previous studies have shown that several genes associated with the causes of PD can influence neurite outgrowth. Mutations of PRKN (encoding parkin, an...

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PMID: 32156628
DOI: 10.1016/j.brainresbull.2020.03.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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