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Article

AI-Predicted Protein Deformation Encodes Energy Landscape Perturbation.

Physical review letters - 30 Aug 2024

McBride John M, Tlusty Tsvi

Abstract excerpt

AI algorithms have proven to be excellent predictors of protein structure, but whether and how much these algorithms can capture the underlying physics remains an open question. Here, we aim to test this question using the Alphafold2 (AF) algorithm: We use AF to predict the subtle structural deformation induced by single mutations, quantified by strain, and compare with experimental datasets of corresponding...

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Identifiers

PMID: 39270162
DOI: 10.1103/PhysRevLett.133.098401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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