Article

Emergency-granulopoiesis trajectory, but not the CD4/NK lymphocyte trajectory, is directionally reproduced as a correlate of sepsis mortality: a cross-cohort transcriptomic study with external testing and clinical-analogue triangulation

2026-08-06

Abstract excerpt

In early sepsis the direction in which blood immune-cell transcriptional programmes move may carry prognostic information beyond a single baseline measurement, but whether such trajectory associations survive independent testing is unknown. We scored five immune modules, frozen before analysis, in three public longitudinal whole-blood microarray sepsis cohorts and fitted a logistic model ladder fixed in advance to...

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Literature Corpus work: 12da9a20-bba0-5c7a-ba57-82000e72b6f0
DOI: 10.64898/2026.08.04.26359671

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Emergency-granulopoiesis trajectory, but not the CD4/NK lymphocyte trajectory, is directionally reproduced as a correlate of sepsis mortality: a cross-cohort transcriptomic study with external testing and clinical-analogue triangulationDOI 10.64898/2026.08.04.26359671Read

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