Article

Reduced lactylation-regulator expression coupled with glycolytic activation marks an immunometabolic state associated with clinical stratification in sepsis

2026-06-26

Abstract excerpt

<title>Abstract</title> <p>Background Sepsis is characterized by heterogeneous host responses and high mortality. Blood lactate is a central clinical marker, and lysine lactylation provides a route through which lactate-derived metabolism may influence transcription and immune-cell function. Whether canonical lactylation regulators are transcriptionally altered when glycolytic and lactate-associated programs are...

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Literature Corpus work: 318a302a-7514-57ac-8927-8af5aef1594b
DOI: 10.21203/rs.3.rs-10139983/v1

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