Article

‘Trans-differentiation of neutrophils from plasmablast’ is an artefact caused by over-reliance on machine algorithms in single cell RNA sequencing analysis: Lesson learnt and steps ahead

2025-02-07

Abstract excerpt

Single cell RNA sequencing (scRNA-seq) provides new opportunities to characterize gene expression for individual cells. However, the sparse nature of the scRNA-seq data with many zero counts or missing values presents a major challenge to its analysis. The presence of low-quality cells further complicates the analysis. Here, we showed that the trans-differentiation of plasmablasts (activated plasma cells) into neu...

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Literature Corpus work: f166157a-d46e-5ffc-9909-9f480ba643f7
DOI: 10.1101/2025.02.07.636761

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