International Validation of Temperature-Trajectory Sepsis Subphenotypes With Longitudinal Immune and Coagulation Patterns and Its Implications for Immunoglobulin Therapy.

doi:10.1097/CCM.0000000000007227

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Article

International Validation of Temperature-Trajectory Sepsis Subphenotypes With Longitudinal Immune and Coagulation Patterns and Its Implications for Immunoglobulin Therapy.

Critical care medicine - 1 Sept 2026

Wang Luhao, Pei Fei, Gu Bin, Navya Tippananapalya Ramesh, Long Hanyan, Guan Xiangdong, Wu Jianfeng, Bhavani Sivasubramanium V

Abstract excerpt

OBJECTIVES: Sepsis remains a major challenge in the ICU. Given the limitations of the one-size-fits-all strategy, precision medicine approaches are needed to identify distinct sepsis subtypes that may respond to different treatments. This study aimed to validate a temperature-trajectory model of sepsis developed in U.S. centers in a non-U.S. cohort from China, to characterize longitudinal immune and coagulation...

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Topics

Humans
Sepsis
Female
Male
Retrospective Studies
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Intensive Care Units

Blood Coagulation

China

Aged

Immunoglobulins

Phenotype

Body Temperature

Source

Open in PubMed

Identifiers

PMID: 42267870
DOI: 10.1097/CCM.0000000000007227

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