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A pan-variant miniprotein inhibitor protects against SARS-CoV-2 variants

2024-08-10

Abstract excerpt

The continued evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has compromised neutralizing antibody responses elicited by prior infection or vaccination and abolished the utility of most monoclonal antibody therapeutics. We previously described a computationally-designed, homotrimeric miniprotein inhibitor, designated TRI2-2, that protects mice against pre-Omicron SARS-CoV-2 variants. Her...

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Identifiers and source

Literature Corpus work
12d250e7-a409-547b-9f20-0396a04dc2be
DOI
10.1101/2024.08.08.606885
Open publication

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A pan-variant miniprotein inhibitor protects against SARS-CoV-2 variantsDOI 10.1101/2024.08.08.606885
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