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Biparatopic nanobodies protect mice from lethal challenge with SARS‐CoV‐2 variants of concern

20 Dec 2021

Abstract excerpt

The ongoing COVID-19 pandemic and the emergence of new SARS-CoV-2 variants of concern (VOCs) requires continued development of effective therapeutics. Recently, we identified high-affinity neutralizing nanobodies (Nbs) specific for the receptor-binding domain (RBD) of SARS-CoV-2. Taking advantage of detailed epitope mapping, we generate two biparatopic Nbs (bipNbs) targeting a conserved epitope outside and two...

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PMID: 34927793
DOI: 10.15252/embr.202153865

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