Article

Persister cancer cells are characterized by H4K20me3 heterochromatin that defines a low inflammatory profile

2024-01-29

Abstract excerpt

<h4>SUMMARY</h4> Anti-cancer therapies may induce proliferative arrest in cancer cells in the form of senescence or drug-tolerant persistency, the latter being a reversible arrest with similarities to embryonic diapause. Here, we use mTOR/PI3K inhibition to develop and characterize a model of persistency/diapause-like arrest in human cancer cells of various origins. We show that persister and senescent cancer cel...

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Literature Corpus work: 12c40447-fe02-518e-ac65-73e801c1791c
DOI: 10.1101/2024.01.26.577389

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