Article

Cycling cancer persister cells arise from lineages with distinct transcriptional and metabolic programs

2020-06-05

Abstract excerpt

Non-genetic mechanisms have recently emerged as important drivers of therapy failure in cancer (Salgia and Kulkarni, 2018), where some cancer cells can enter a reversible drug-tolerant persister state in response to treatment (Vallette et al., 2019). While most cancer persisters, like their bacterial counterparts, remain arrested in the presence of drug, a rare subset of cancer persisters can re-enter the cell cyc...

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Literature Corpus work: 866faee6-66c5-5db2-95ab-2e5103bbf4ba
DOI: 10.1101/2020.06.05.136358

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