Article

mTOR is a Major Determinant of Chemosensitivity

2022-01-21

Abstract excerpt

<h4>ABSTRACT</h4> Chemotherapy can eradicate a majority of cancer cells. However, a small population of tumor cells often survives drug treatments through genetic and/or non-genetic mechanisms, leading to tumor recurrence. Here we report a reversible chemoresistance phenotype regulated by the mTOR pathway. Through a genome-wide CRISPR knockout library screen in pancreatic cancer cells treated with chemotherapeuti...

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Literature Corpus work: 681af720-092f-59eb-afc9-279ec1476849
DOI: 10.1101/2022.01.19.476916

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