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Drug-Tolerant Persister Cells in Cancer Therapy Resistance

18 May 2022

Abstract excerpt

One of the current stumbling blocks in our fight against cancer is the development of acquired resistance to therapy, which is attributable to approximately 90% of cancer-related deaths. Undercutting this process during treatment could significantly improve cancer management. In many cases, drug resistance is mediated by a drug-tolerant persister (DTP) cell subpopulation present in tumors, often referred to as...

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PMID: 35584245
DOI: 10.1158/0008-5472.can-21-3844

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