Drug-tolerant persister cell in cancer: reversibility, microenvironmental interplay, and therapeutic strategies

Abstract excerpt

Drug-tolerant persister (DTP) cells are a subpopulation of cancer cells capable of surviving therapeutic stress through reversible, non-genetic adaptations. These cells contribute to minimal residual disease and eventual tumor relapse. Understanding the mechanisms that govern the entry into and exit from the DTP state-such as epigenetic remodeling, metabolic rewiring, and transcriptional plasticity-reveals...

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