Article

Harnessing homeostatically active RhoC at cell junctions preserves human endothelial barrier function during inflammation

2024-05-19

Abstract excerpt

<h4>ABSTRACT</h4> Rho GTPases are molecular targets of bacterial toxins that modulate their enzymatic activity. RhoA, RhoB and RhoC are almost identical and play critical roles in generating actomyosin-mediated contractile forces that cause endothelial hyperpermeability during inflammation. Searching for new treatments to modulate endothelial integrity, we demonstrate that the specific and simultaneous activation...

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Literature Corpus work: 12be39c4-9c9a-59f6-8e6d-46170a39c3cd
DOI: 10.1101/2024.05.17.594667

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