Article
Direct activation of RhoA by reactive oxygen species requires a redox-sensitive motif.
PloS one - 26 Nov 2009
Aghajanian Amir, Wittchen Erika S, Campbell Sharon L, Burridge Keith
Abstract excerpt
BACKGROUND: Rho family GTPases are critical regulators of the cytoskeleton and affect cell migration, cell-cell adhesion, and cell-matrix adhesion. As with all GTPases, their activity is determined by their guanine nucleotide-bound state. Understanding how Rho proteins are activated and inactivated has largely focused on regulatory proteins such as guanine nucleotide exchange factors (GEFs) and GTPase activating...
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