Article
Expansion of stemlike HIV-specific CD8+ T cells and limited viral epitope diversity characterize durable posttreatment control of HIV.
Science translational medicine - 22 Apr 2026
Crain Charles R, Alrubayyi Aljawharah, Muzhingi Itai, Traunbauer Anna, Jeon Esther, Deo Rinki, Deligiannidis Efthimios A, Shrestha Prerana, Etemad Behzad, MacLeod Hannah, Laird Gregory M, Choudhary Manish C, Peluso Michael J, Deeks Steve G, Rutishauser Rachel L, Li Jonathan Z, Gaiha Gaurav D
Abstract excerpt
Individuals who durably control HIV after cessation of antiretroviral therapy (ART) are of great interest for HIV cure efforts, but the correlates of posttreatment control remain incompletely understood. Here, we show across a diverse cohort of posttreatment controllers (PTCs), posttreatment noncontrollers (NCs), and spontaneous elite controllers (ECs) that robust expansion of HIV-specific CD8+ T cells and...
Topics
- Humans
- CD8-Positive T-Lymphocytes
- HIV Infections
- Epitopes
- HIV-1
- Cell Proliferation
- Female
- Immunologic Memory
- Phenotype