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TNF and type I IFN induction of the IRG1-itaconate pathway restricts <i>Coxiella burnetii</i> replication within mouse macrophages

2023-07-07

Abstract excerpt

The intracellular Gram-negative bacterium Coxiella burnetii replicates within macrophages and causes a zoonotic disease known as Q fever. In murine macrophages, the cytokine tumor necrosis factor (TNF) is critical for restriction of intracellular C. burnetii replication. Here, we show that TNF collaborates with type I interferon (IFN) signaling for maximal control of C. burnetii . We found that TNF and type I I...

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Identifiers and source

Literature Corpus work
e2b81f4b-84b7-5f91-af61-98a90a662231
DOI
10.1101/2023.07.07.548079
Open publication

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TNF and type I IFN induction of the IRG1-itaconate pathway restricts <i>Coxiella burnetii</i> replication within mouse macrophagesDOI 10.1101/2023.07.07.548079
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