Article

Enhanced oxidative phosphorylation in Retinoblastoma tumors is dependent on depleted Hexokinase1 and lack of AMPKα activation

2022-08-01

Abstract excerpt

Lack of retinoblastoma protein (Rb) causes aggressive intraocular retinal tumors in children. Recently, Rb tumors have been shown to have a distinctly altered metabolic phenotype, such as reduced expression of glycolytic pathway proteins alongside altered pyruvate and fatty acid levels. In this study, we demonstrate that loss of Hexokinase 1(HK1) in tumor cells rewires their metabolism allowing enhanced oxidative...

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Literature Corpus work: 12aff508-54a5-52bb-9b44-8cc49e1c1c96
DOI: 10.21203/rs.3.rs-1779138/v1

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