Article
Depleted hexokinase1 and lack of AMPKα activation favor OXPHOS-dependent energetics in retinoblastoma tumors.
Translational research : the journal of laboratory and clinical medicine - 1 Nov 2023
Babu Vishnu Suresh, Mallipatna Ashwin, Dudeja Gagan, Shetty Rohit, Nair Archana Padmanabhan, Tun Sai Bo Bo, Ho Candice Ee Hua, Chaurasia Shyam S, Bhattacharya Shomi S, Verma Navin Kumar, Lakshminarayanan Rajamani, Guha Nilanjan, Heymans Stephane, Barathi Veluchamy Amutha, Ghosh Arkasubhra
Abstract excerpt
Lack of retinoblastoma (Rb) protein causes aggressive intraocular retinal tumors in children. Recently, Rb tumors have been shown to have a distinctly altered metabolic phenotype, such as reduced expression of glycolytic pathway proteins alongside altered pyruvate and fatty acid levels. In this study, we demonstrate that loss of hexokinase 1(HK1) in tumor cells rewires their metabolism allowing enhanced oxidative...
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