Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pyruvate dehydrogenase inactivation causes glycolytic phenotype in BAP1 mutant uveal melanoma.

Oncogene - 1 Feb 2022

Han Anna, Chua Vivian, Baqai Usman, Purwin Timothy J, Bechtel Nelisa, Hunter Emily, Tiago Manoela, Seifert Erin, Speicher David W, Schug Zachary T, Harbour J William, Aplin Andrew E

Abstract excerpt

Effective therapeutic options are still lacking for uveal melanoma (UM) patients who develop metastasis. Metastatic traits of UM are linked to BRCA1-associated protein 1 (BAP1) mutations. Cell metabolism is re-programmed in UM with BAP1 mutant UM, but the underlying mechanisms and opportunities for therapeutic intervention remain unclear. BAP1 mutant UM tumors have an elevated glycolytic gene expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Neoplastic
Share to Glycolysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melanoma

Share to Phosphorylation

Share to Tumor Suppressor Proteins

Share to Ubiquitin Thiolesterase

Share to Uveal Melanoma

Share to Uveal Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 35046531
DOI: 10.1038/s41388-021-02154-0
PMCID: PMC9066178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pyruvate dehydrogenase inactivation causes glycolytic phenotype in BAP1 mutant uveal melanoma.PMID 35046531Read ↗

BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors.Semantic proximity Read ↗

Slow proliferation of BAP1-deficient uveal melanoma cells is associated with reduced S6 signaling and resistance to nutrient stress.Semantic proximity Read ↗

Regulation of phosphoglycerate kinase 1 and its critical role in cancerSemantic proximity Read ↗

Melanoma Metabolism: Molecular Mechanisms and Therapeutic Implications in Cutaneous OncologySemantic proximity Read ↗

Metabolic Alterations and Therapeutic Opportunities in Rare Forms of Melanoma.Semantic proximity Read ↗

Comprehensive analyses of PDHA1 that serves as a predictive biomarker for immunotherapy response in cancerSemantic proximity Read ↗

The AMP-dependent kinase pathway is upregulated in BAP1 mutant uveal melanoma.Semantic proximity Read ↗

Hypoxia-induced BNIP3 facilitates the progression and metastasis of uveal melanoma by driving metabolic reprogrammingSemantic proximity Read ↗

Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis.Semantic proximity Read ↗

Wild-type IDH1 inhibition enhances chemotherapy response in melanoma.Semantic proximity Read ↗

The metabolic microenvironment of melanomas: Prognostic value of MCT1 and MCT4Semantic proximity Read ↗

Wild-type IDH1 inhibition enhances chemotherapy response in melanomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.