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Hypoglycemia Enhances Epithelial-Mesenchymal Transition and Invasiveness, and Restrains the Warburg Phenotype, in Hypoxic HeLa Cell Cultures and Microspheroids.

Journal of cellular physiology - 1 Jun 2017

Marín-Hernández Álvaro, Gallardo-Pérez Juan Carlos, Hernández-Reséndiz Ileana, Del Mazo-Monsalvo Isis, Robledo-Cadena Diana Xochiquetzal, Moreno-Sánchez Rafael, Rodríguez-Enríquez Sara

Abstract excerpt

The accelerated growth of solid tumors leads to episodes of both hypoxia and hypoglycemia (HH) affecting their intermediary metabolism, signal transduction, and transcriptional activity. A previous study showed that normoxia (20% O2 ) plus 24 h hypoglycemia (2.5 mM glucose) increased glycolytic flux whereas oxidative phosphorylation (OxPhos) was unchanged versus normoglycemia in HeLa cells. However, the...

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PMID: 27661776
DOI: 10.1002/jcp.25617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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