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Article

The connexin 43 regulator Rotigaptide reduces cytokine-induced cell death in human islets

2018-05-21

Abstract excerpt

<h4>Abstarct</h4> <h4>Background</h4> Intercellular communication mediated by cationic fluxes through the Connexin-family of gap-junctions regulates glucose-stimulated insulin-secretion and beta-cell defense against inflammatory stress. Rotigaptide (RG, ZP123) is a peptide analog that increases intercellular conductance in cardiac muscle-cells by prevention of dephosphorylation and thereby uncoupling of Connexin...

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Literature Corpus work
12ab36d7-ba42-50be-ba50-bb3c13c934d8
DOI
10.1101/327171
Open publication

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The connexin 43 regulator Rotigaptide reduces cytokine-induced cell death in human isletsDOI 10.1101/327171
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