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Article

Activation of the NLRP3 inflammasome complex is not required for stress-induced death of pancreatic islets.

PloS one - 1 Jan 2014

Wali Jibran A, Gurzov Esteban N, Fynch Stacey, Elkerbout Lorraine, Kay Thomas W, Masters Seth L, Thomas Helen E

Abstract excerpt

Loss of pancreatic beta cells is a feature of type-2 diabetes. High glucose concentrations induce endoplasmic reticulum (ER) and oxidative stress-mediated apoptosis of islet cells in vitro. ER stress, oxidative stress and high glucose concentrations may also activate the NLRP3 inflammasome leading to interleukin (IL)-1β production and caspase-1 dependent pyroptosis. However, whether IL-1β or intrinsic NLRP3...

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Source

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Identifiers

PMID: 25405767
DOI: 10.1371/journal.pone.0113128
PMCID: PMC4236141

Genes

NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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