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Article

Aleglitazar, a dual peroxisome proliferator-activated receptor-α and -γ agonist, protects cardiomyocytes against the adverse effects of hyperglycaemia.

Diabetes & vascular disease research - 1 Mar 2017

Chen Yan, Chen Hongmei, Birnbaum Yochai, Nanhwan Manjyot K, Bajaj Mandeep, Ye Yumei, Qian Jinqiao

Abstract excerpt

PURPOSE: To assess the effects of Aleglitazar on hyperglycaemia-induced apoptosis. METHODS: We incubated human cardiomyocytes, cardiomyocytes from cardiac-specific peroxisome proliferator-activated receptor-γ knockout or wild-type mice in normoglycaemic or hyperglycaemic conditions (glucose 25 mM). Cells were treated with different concentrations of Aleglitazar for 48 h. We measured viability, apoptosis,...

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Identifiers

PMID: 28111985
DOI: 10.1177/1479164116679081
PMCID: PMC5305042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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