Article

Methadone alters transcriptional programs associated with synapse formation in human cortical organoids

2022-11-05

Abstract excerpt

<h4>ABSTRACT</h4> Opioid use disorder (OUD) among pregnant women has become an epidemic in the United States. Pharmacological interventions for OUD involve methadone, a synthetic opioid analgesic that attenuates withdrawal symptoms and behaviors linked with maternal drug abuse. However, methadone’s ability to readily accumulate in neural tissue, and cause long-term neurocognitive sequelae, has led to concerns reg...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 925d4427-ce02-5291-b51e-31e5575ac003
DOI: 10.1101/2022.11.04.515240

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Methadone alters transcriptional programs associated with synapse formation in human cortical organoidsDOI 10.1101/2022.11.04.515240Read

Chronic opioid treatment arrests neurodevelopment and alters synaptic activity in human midbrain organoidsSemantic proximity Read

Dual Transcriptomic and Epigenomic Signatures of THC Exposure in Human Prefrontal Cortex DevelopmentSemantic proximity Read

Benchmarking brain organoid recapitulation of fetal corticogenesisSemantic proximity Read

Transcriptomic changes due to early, chronic alcohol exposure during cortical development implicate regionalization, cell-type specification, synaptogenesis and WNT signaling as primary determinants of fetal alcohol Spectrum DisordersSemantic proximity Read

Brain-Derived Extracellular Vesicle microRNA Signatures Associated with In Utero and Postnatal Oxycodone ExposureSemantic proximity Read

Multi-omics identification of extracellular components of the fetal monkey and human neocortexSemantic proximity Read

Molecular and long-term behavioral consequences of neonatal opioid exposure and withdrawal in miceSemantic proximity Read

Therapeutic acetaminophen exposure does not measurably alter human cortical organoid developmentSemantic proximity Read

Three Years Follow-Up Study Showed Prenatal Methamphetamine Exposure May Cause Chronic Abnormalities In Transcriptomic PatternSemantic proximity Read

Effect of Prenatal Opioid Exposure on the Human Placental MethylomeSemantic proximity Read

Maternal Opioid Exposure Culminates in Perturbed Murine Neurodevelopment and Hyperactive Phenotype in Adolescence.Semantic proximity Read

Prenatal Methamphetamine Exposure could Cause Chronic Abnormalities in Transcriptomic Pattern; an Extended Follow-up Cohort StudySemantic proximity Read