Article

Single cell assessment of human stem cell derived mesolimbic models and their responses to substances of abuse

2023-05-14

Abstract excerpt

The mesolimbic pathway connects ventral tegmental area dopaminergic neurons and striatal medium spiny neurons, playing a critical role in reward and stress behaviors. Exposure to substances of abuse during development and adulthood has been linked to adverse outcomes and molecular changes. The rise of human cell repositories and whole genome sequences enables human functional genomics ‘in a dish’, offering insight...

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Literature Corpus work: 62484f53-975a-5b03-b1a6-206e41eb9c60
DOI: 10.1101/2023.05.12.540534

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