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Article

Sevoflurane promotes premature differentiation of dopaminergic neurons in hiPSC-derived midbrain organoids

13 Sept 2022

Abstract excerpt

Background: Conventional animal models used in corresponding basic studies are distinct from humans in terms of the brain’s development trajectory, tissue cytoarchitecture and cell types, making it difficult to accurately evaluate the potential adverse effects of anesthetic treatments on human fetal brain development. This study investigated the effects of sevoflurane on the midbrain’s development and...

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PMID: 36176283
DOI: 10.3389/fcell.2022.941984

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