Hormonal modulation of ESR1 mutant metastasis.

doi:10.1038/s41388-020-01563-x

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Article

Hormonal modulation of ESR1 mutant metastasis.

Oncogene - 1 Feb 2021

Gu Guowei, Tian Lin, Herzog Sarah K, Rechoum Yassine, Gelsomino Luca, Gao Meng, Du Lili, Kim Jin-Ah, Dustin Derek, Lo Hin Ching, Beyer Amanda R, Edwards David G, Gonzalez Thomas, Tsimelzon Anna, Huang Helen J, Fernandez Natalie M, Grimm Sandra L, Hilsenbeck Susan G, Liu Dan, Xu Jun, Alaniz Alyssa, Li Shunqiang, Mills Gordon B, Janku Filip, Kittler Ralf, Zhang Xiang H-F, Coarfa Cristian, Foulds Charles E, Symmans W Fraser, Andò Sebastiano, Fuqua Suzanne A W

Abstract excerpt

Estrogen receptor alpha gene (ESR1) mutations occur frequently in ER-positive metastatic breast cancer, and confer clinical resistance to aromatase inhibitors. Expression of the ESR1 Y537S mutation induced an epithelial-mesenchymal transition (EMT) with cells exhibiting enhanced migration and invasion potential in vitro. When small subpopulations of Y537S ESR1 mutant cells were injected along with WT parental...

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PMID: 33323970
DOI: 10.1038/s41388-020-01563-x
PMCID: PMC8020875

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