Article

<i>ESR1</i> mutant breast cancers show elevated basal cytokeratins and immune activation

2020-12-30

Abstract excerpt

Estrogen receptor alpha (ER/ ESR1 ) is mutated in 30-40% of endocrine resistant ER-positive (ER+) breast cancer. ESR1 mutations cause ligand-independent growth and increased metastasis in vivo and in vitro . Despite the distinct clinical features and changes in therapeutic response associated with ESR1 mutations, there are no data about their potential role in intrinsic subtype switching. Applying four lumina...

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Literature Corpus work: 16a995c5-d4e2-56ef-a78f-64c0ef76848e
DOI: 10.1101/2020.12.29.424777

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