Article
Hotspot ESR1 Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis.
Cancer research - 1 Apr 2022
Li Zheqi, Wu Yang, Yates Megan E, Tasdemir Nilgun, Bahreini Amir, Chen Jian, Levine Kevin M, Priedigkeit Nolan M, Nasrazadani Azadeh, Ali Simak, Buluwela Laki, Arnesen Spencer, Gertz Jason, Richer Jennifer K, Troness Benjamin, El-Ashry Dorraya, Zhang Qiang, Gerratana Lorenzo, Zhang Youbin, Cristofanilli Massimo, Montanez Maritza A, Sundd Prithu, Wallace Callen T, Watkins Simon C, Fumagalli Caterina, Guerini-Rocco Elena, Zhu Li, Tseng George C, Wagle Nikhil, Carroll Jason S, Jank Paul, Denkert Carsten, Karsten Maria M, Blohmer Jens-Uwe, Park Ben H, Lucas Peter C, Atkinson Jennifer M, Lee Adrian V, Oesterreich Steffi
Abstract excerpt
Constitutively active estrogen receptor α (ER/ESR1) mutations have been identified in approximately one-third of ER+ metastatic breast cancers. Although these mutations are known as mediators of endocrine resistance, their potential role in promoting metastatic disease has not yet been mechanistically addressed. In this study, we show the presence of ESR1 mutations exclusively in distant but not local recurrences...
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