Article

A Continuous Metric to Measure Endotype and Corticosteroid Interaction in Septic Shock

2021-05-05

Abstract excerpt

<title>Abstract</title> <p>The benefit of corticosteroids for septic shock remains unclear, reflecting heterogeneity of treatment effect. We previously reported a binary septic shock endotype classification based on expression of 100 genes. This binary classification provides information regarding prognosis and corticosteroid responsiveness but does not capture the endotypes continuum. Here, we describe a continu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 123dbc82-0094-5856-b44e-a5197009119f
DOI: 10.21203/rs.3.rs-414721/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Continuous Metric to Measure Endotype and Corticosteroid Interaction in Septic ShockDOI 10.21203/rs.3.rs-414721/v1Read

Derivation, validation, and transcriptomic assessment of pediatric septic shock phenotypes identified through latent profile analyses: Results from a prospective multi-center observational cohortSemantic proximity Read

Identification and transcriptomic assessment of latent profile pediatric septic shock phenotypes.Semantic proximity Read

Validation of a gene expression-based subclassification strategy for pediatric septic shock*Semantic proximity Read

Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study.Semantic proximity Read

Machine learning driven identification of gene-expression signatures correlated with multiple organ dysfunction trajectories and complex sub-endotypes of pediatric septic shockSemantic proximity Read

Defining critical illness using immunological endotypes in patients with and without of sepsis: A cohort studySemantic proximity Read

Transcriptomic mortality signature defines high-risk neonatal sepsis endotypeSemantic proximity Read

Developing a clinically feasible personalized medicine approach to pediatric septic shock.Semantic proximity Read

Inflammatory sub-phenotypes in sepsis: relationship to outcomes, treatment effect and transcriptomic sub-phenotypesSemantic proximity Read

Molecular Phenotyping of Patients with Sepsis and Kidney Injury and Differential Response to Fluid ResuscitationSemantic proximity Read

A Multivariate Phenotypical Approach of Sepsis and Septic Shock-A Comprehensive Narrative Literature Review.Semantic proximity Read

A Multivariate Phenotypical Approach of Sepsis and Septic Shock – a Comprehensive Narrative Literature ReviewSemantic proximity Read