Article
Identification and transcriptomic assessment of latent profile pediatric septic shock phenotypes.
Critical care (London, England) - 17 Jul 2024
Atreya Mihir R, Huang Min, Moore Andrew R, Zheng Hong, Hasin-Brumshtein Yehudit, Fitzgerald Julie C, Weiss Scott L, Cvijanovich Natalie Z, Bigham Michael T, Jain Parag N, Schwarz Adam J, Lutfi Riad, Nowak Jeffrey, Thomas Neal J, Quasney Michael, Dahmer Mary K, Baines Torrey, Haileselassie Bereketeab, Lautz Andrew J, Stanski Natalja L, Standage Stephen W, Kaplan Jennifer M, Zingarelli Basilia, Sahay Rashmi, Zhang Bin, Sweeney Timothy E, Khatri Purvesh, Sanchez-Pinto L Nelson, Kamaleswaran Rishikesan
Abstract excerpt
BACKGROUND: Sepsis poses a grave threat, especially among children, but treatments are limited owing to heterogeneity among patients. We sought to test the clinical and biological relevance of pediatric septic shock subclasses identified using reproducible approaches. METHODS: We performed latent profile analyses using clinical, laboratory, and biomarker data from a prospective multi-center pediatric septic shock...
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