Article
Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study.
The Lancet. Respiratory medicine - 1 Oct 2017
Scicluna Brendon P, van Vught Lonneke A, Zwinderman Aeilko H, Wiewel Maryse A, Davenport Emma E, Burnham Katie L, Nürnberg Peter, Schultz Marcus J, Horn Janneke, Cremer Olaf L, Bonten Marc J, Hinds Charles J, Wong Hector R, Knight Julian C, van der Poll Tom
Abstract excerpt
BACKGROUND: Host responses during sepsis are highly heterogeneous, which hampers the identification of patients at high risk of mortality and their selection for targeted therapies. In this study, we aimed to identify biologically relevant molecular endotypes in patients with sepsis. METHODS: This was a prospective observational cohort study that included consecutive patients admitted for sepsis to two intensive...
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