Validation of a gene expression-based subclassification strategy for pediatric septic shock*

Abstract excerpt

OBJECTIVE: Septic shock heterogeneity has important implications for clinical trial implementation and patient management. We previously addressed this heterogeneity by identifying three putative subclasses of children with septic shock based exclusively on a 100-gene expression signature. Here we attempted to prospectively validate the existence of these gene expression-based subclasses in a validation cohort....

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