Article

VAMP8 contributes to TRIM6-mediated type-I interferon antiviral response during West Nile virus infection

2018-12-01

Abstract excerpt

<h4>ABSTRACT</h4> Members of the tripartite motif (TRIM) family of E3 ubiquitin ligases regulate immune pathways including the antiviral type I interferon (IFN-I) system. Previously, we demonstrated that TRIM6 is involved in IFN-I induction and signaling. In absence of TRIM6 function, optimal IFN-I signaling is reduced, allowing increased replication of interferon-sensitive viruses. Despite numerous mechanisms to...

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Literature Corpus work: 3444749c-b7ee-54f9-b3c2-afb0b33c1407
DOI: 10.1101/484469

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