Article

VAMP8 contributes to TRIM6-mediated type-I interferon antiviral response during West Nile virus infection

2019-08-28

Abstract excerpt

<h4>ABSTRACT</h4> Several members of the tripartite motif (TRIM) family of E3 ubiquitin ligases regulate immune pathways including the antiviral type I interferon (IFN-I) system. Previously, we demonstrated that TRIM6 is involved in IFN-I induction and signaling. In the absence of TRIM6, optimal IFN-I signaling is reduced, allowing increased replication of interferon-sensitive viruses. Despite having evolved nume...

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Literature Corpus work: e7eaffbe-0bef-5ffa-85f7-71a8bf1ed696
DOI: 10.1101/749853

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