Article

Single-cell resolution uncovers cell type-specific dysregulation in Parkin-deficient neuron-microglia co-cultures

2026-03-27

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Mutations in the E3 ubiquitin ligase Parkin (encoded by PRKN ) are the most frequently known cause of recessively inherited Parkinson’s disease. In addition to the loss of dopaminergic neurons, microglial activation is another pathological feature observed in Parkinson’s disease. While postmortem brain samples show the end stage of the disease, neurons and glia derived from...

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Literature Corpus work: 122dbd39-155e-5963-a6fa-3d74195a079a
DOI: 10.64898/2026.03.27.714690

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