Article

CCR5 deficiency: decreased neuronal resilience to oxidative stress and increased risk of vascular dementia

2023-02-16

Abstract excerpt

<h4>Introduction</h4> As the chemokine receptor5 (CCR5) may play a role in ischemia, we studied the links between CCR5 deficiency, the sensitivity of neurons to oxidative stress, and the development of dementia. <h4>Methods</h4> Logistic regression models with CCR5 and ApoE polymorphisms were applied to 205 cognitively normal and 189 dementia patients included in Geneva. The impact of oxidative stress on Ccr5 expr...

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Literature Corpus work: 1219f335-b073-59b5-979f-19110b2cfef9
DOI: 10.1101/2023.02.15.23285967

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